Importance of Technical Education Essay

Training is significant for each person in a country. It assumes an essential job to change the gaze of a nation. No nation could acquire an upheaval it except if its everyone are taught enough to address the difficulties. Training causes a man to acknowledge about himself and his objectives and how to accomplish that objectives. Essentially, Education is separated into three gatherings. The Education which instructs the worries of a general public is called Social Education. The Education which builds up a character inside a man himself is called Spiritual Education. The Education that worries with the demonstrable skill is called Vocational Education. The Technical Education goes under the part of Vocational Education which bargains essentially in the field of exchange, trade, agribusiness, medication and Engineering. We are living in the cutting edge period of science where we discovered Technologies in each part of life. What makes life so mind agreeable for us essentially; these are the Technologies which we use for our straightforwardness and solaces. In our day by day life as well as in the exploration community, in protective estimated of a nation, natural perspectives and so forth. No country could produce the advancement except if it advances specialized perspectives in its fields. The specialized instruction produces experts for all kind of ventures and the facts confirm that the advancement of a nation much rely on its Industrialization without which an attractive economy would not be conceivable. Utilizing an innovation is far simpler than to create it. For building up an innovation, it required high aptitude groups which have a high information for the subject. It likewise required a high measure of time and furthermore cash. To satisfy all these, there must be specialized organizations which must cover all the resources of mechanical examinations and furthermore the help of government to help monetarily and to contruct it at universal level. On the off chance that it would be at International level, at that point it is simpler to understudies to snatch information in their own state with the goal that they could accomplish something for their own nation. Pakistan leads in the innovative time. The show lopes in Pakistan assumes a fundamental job in maneuvering up the specialists to concoct an ever increasing number of new innovations since it gives impression of our advances to the outsiders which are speaking to their nation, which implies we are mirroring our picture to that world. By this we have a feeling of advancement and success that we additionally produce inventive brain in the innovative angle. To the extent Pakistans usage in techno field is concern, we may glance around and see that in each field of life we are utilizing high class advances whether it is in the Industrial reason, business reason, agribusiness reason or cautious reason. There has been a ton of rise of on-line exchanging, which manages high innovative worries in term of hardware and programming. Pakistan Telecommunication field likewise manage high-class innovation. Pakistan likewise vows to create best professionals of its own through their specialized training places which permit roughly all the resources for specialized turn of events. These organizations additionally bolster the new courses of innovation which are presented at a moment so that there would be no line at which we lay behind. The most significant establishments of in Pakistan which bolster the specialized courses join, NED University, GIK University, Karachi University, Mehran University and there are likewise some other private Universities which bargain in mechanical subjects. These foundations guarantee to create experts who cold address the difficulties of the mechanical period. I feel glad when I watch the understudies surging towards these specialized establishments to turn into a prosperous expert who have an awareness of other's expectations for the advancement of their country. Specialized instruction advances the material flourishing and financial progression. It delivers the feeling of sense of pride and nobility. In the event that a nation has her own specialized specialists, she may spare a ton of remote trade I. e. Specialized Education makes a nation rich, prosperous and clever. Our nation is wealthy in crude material assets however the thing is, we should have enough specialized data to profit by them.

How to Convert Kelvin to Fahrenheit

Instructions to Convert Kelvin to Fahrenheit Kelvin and Fahrenheit are two significant temperature scales. Kelvin is a standard measurement scale, with a degree a similar size as the Celsius degree yet with its zero point at supreme zero. Fahrenheit is the temperature most usually utilized in the United States. Luckily, its easy to change over between the two scales, giving you know the condition. Kelvin to Fahrenheit Conversion Formula Here is the recipe to change over Kelvin to Fahrenheit:  ° F 9/5(K - 273) 32 or on the other hand you may see the condition utilizing increasingly huge figures as:  ° F 9/5(K - 273.15) 32 or then again  ° F 1.8(K - 273) 32 You can utilize whichever condition you like. It is anything but difficult to change over Kelvin to Fahrenheit with these four stages. Deduct 273.15 from your Kelvin temperatureMultiply this number by 1.8 (this is the decimal estimation of 9/5).Add 32 to this number. Your answer will be the temperature in degrees Fahrenheit. Kelvin to Fahrenheit Conversion Example Lets attempt an example issue, changing over room temperature in Kelvin to degrees Fahrenheit. Room temperature is 293K. Start with the condition (I picked the one with less noteworthy figures):  ° F 9/5(K - 273) 32 Plug in the incentive for Kelvin: F 9/5(293 - 273) 32 Figuring it out: F 9/5(20) 32F 36 32F 68 Fahrenheit is communicated utilizing degrees, so the appropriate response is that room temperature is 68â ° F. Fahrenheit to Kelvin Conversion Example Lets attempt the transformation the other way. For instance, say you need to change over human internal heat level, 98.6â ° F, into its Kelvin proportionate. You can utilize a similar condition: F 9/5(K - 273) 3298.6 9/5(K - 273) 32 Deduct 32 from the two sides to get:66.6 9/5(K - 273) Duplicate 9/5 times the qualities inside the enclosure to get:66.6 9/5K - 491.4 Get the variable (K) on one side of the condition. I decided to take away (- 491.4) from the two sides of the condition, which is equivalent to adding 491.4 to 66.6:558 9/5K Increase the two sides of the condition by 5 to get:2,790 9K At last, partition the two sides of the condition by 9 to find the solution in K:310 K Along these lines, human internal heat level in Kelvin is 310 K. Keep in mind, Kelvin temperature isn't communicated utilizing degrees, only a capital letter K. Note: You could have utilized another type of the condition, basically revamped to settle for the Fahrenheit to Kelvin transformation: K 5/9(F - 32) 273.15 which is essentially equivalent to stating Kelvin rises to the Celsius esteem in addition to 273.15. Make sure to check your work. The main temperature where the Kelvin and Fahrenheit qualities will be equivalent is at 574.25. More Conversions For additional transformations, see these subjects: Step by step instructions to Convert Celsius to Fahrenheit: The Celsius and Fahrenheit scales are two other significant temperature scales.How to Convert Fahrenheit to Celsius: Use these when you have to change over Fahrenheit to the metric system.How to Convert Celsius to Kelvin: Both scales have a similar size of degree, so this transformation is super easy!How to Convert Kelvin to Celsius: This is a typical temperature transformation in science.

Essay Topics For Teens

Essay Topics For TeensWriting essays for teens is a great opportunity for them to express themselves without parental interference. However, it's important to be sure you choose the right topic for the essay. Here are some examples of essay topics for teens:Spell-checker software - You can use spell-checker software on your computer to help with spelling and grammar. However, you will need to be computer savvy enough to effectively use the software. For example, if you get a letter or email that has spelling mistakes, then you should probably be writing an essay on how to correct those mistakes. You can also find some free tools that can help you manage spelling and grammar.Homework - Make sure you keep an organized schedule for your kids and let them know what they are supposed to do for homework. Make sure you have a weekly homework outline in place. This can help them stick to a schedule. Keep copies of the weekly homework schedule in your house, home, workstation, and on your com puter. Remember, this is your responsibility as a parent!Skills - It's crucial that your children learn something new. Let them know that their skills can be tested through self-tests, and let them know the kinds of skills that you expect from them. They can also use this information to help develop their own skills. Remember to include a self-test on the lesson plans you've prepared, and ask your children to write up a letter, report, essay, etc.Social Skills - Encourage your children's confidence in their social abilities. Ask them to help you pick a game to play, or let them help you decorate the party with paper goods. It's a good idea to set up some time where they can spend some time with you doing something to promote your child's social skills. Social skills are something all kids need, but it can also help them learn more about how to deal with the big situations and challenges in life.Main Idea - If you write a main idea of the essay, make sure you include it in the title. This will give you enough information for the reader to know what the main idea is. The main idea can be anything from your child's experience with social groups, a small part of a major event, a game your child played recently, etc. Make sure that your main idea has an element of surprise!Essay Topics for Teens may also include arts, movies, poetry, literature, etc. Basically anything they are interested in can be covered. Do a little research, read a little, and take the lead by getting started right away.These are just a few essay topics for teens. You may also want to consider writing a kids' story, craft ideas, nature stories, etc. Write down your ideas and see what comes out.

Focus of American Culture using the example strategy - Free Essay Example

Sample details Pages: 4 Words: 1271 Downloads: 8 Date added: 2019/10/10 Did you like this example? The Body Ritual Among the Nacirema By Horace Miner, is a good demonstration that the attitudes that entailing a body have a great influence on many Naciremas’ society. Miner has fundamentally used the article to give a description of the American rituals from a view of an outsider. Reading the article with an understanding of Nacirema as an American is of help in understanding the view of culture by other people. Don’t waste time! Our writers will create an original "Focus of American Culture using the example strategy" essay for you Create order For this reason, using relevant examples, I chose on this paper, to Use the example strategy to address Horace Miner?s ?Body ritual among the Nacirema?, Agree with Miner that our culture?s primary focus is the body, and translate all examples Miner used into their common names. In understanding the Horace Miner?s ?Body ritual among the Nacirema†, one will note that the Nacirema culture is one that is characterized by a market economy that is estimably developed. The market economy has developed to a rich natural habitat. It is seen that a lot of time is spent by people in the economic devoted pursuits. However, a large number of the activities and part of days are being spent in the ritual related activities. All the focus that is in all these activities is on the body not talk of its appearance and its health. This is what puts a great importance in the ethos that guide people. Such an expression is not different and the aspects of the ceremony and the philosophies that are associated here are one of a kind. There is a fundamental belief that the human body has always remained to be ugly. The natural tendency of the body in this case, therefore, has remained to be diseases and debility. Having been incarcerated in such a body, the responsibility of a man is to make sure that he averts these characteristics. All these have to be done through the influences that ceremonies and rituals have. Every household, therefore, has, for instance, a shrine to carry out these ceremonies and rituals. In the shrines, a number of activities are carried out on the body which includes, for instance, the mouth-rite. From a perspective of sociological standpoint, one ends up understanding The Body Ritual Among the Nacirema By Horace Miner. Every culture is based on certain rituals. For this reason, every culture finds itself defining its acceptable behaviors and realities and therefore, it ends up choosing its authorities by its own rituals. The rituals are then what makes people discover the knowledge they have for purpose of making their rituals their own authority. People find themselves following it after they know the whole truth of how the society defines it. What people do repeatedly and on regular basis hence binding people together with for instance assigned roles, shared beliefs, and loyalty is known as culture. It is rituals that have the capability of enforcing these roles and values by supporting them and creating social solidarity. Rituals will always hold a society together even though not all the societies. Rituals will remain to be part of what holds a society together. For this reason, it is always good to always think outside the box with the help of viewing things in an American way. I am in agreement with Miner that our culture?s primary focus is the body. From the concept of the word and the entire concept of body culture, the body culture is what signifies the form in which a physical practice happens. For instance, the life reform has aimed at the reform of nurture and clothing that favors body activities. This is having in mind that clothing or mode of dressing walk hand in hand with the concept of culture. This is what has constituted and constitutes, for instance, sports and gymnastics. The nudism is a good representation of this kind of culture. Most cultures have a tendency of exhibiting a particular style or configuration. As miner goes on to demonstrate the attitudes of the body, hence having a great influence on the society he is from, other societies have a tendency of demonstrating their own culture through the body as well. For instance, the â€Å"machismo† has a pervasive influence in the Spanish culture. On the other hand, the â€Å"faceà ¢â‚¬  in the culture of Japanese and the â€Å"pollution by females† in the highlands of Guinea are seen to have a pervasive influence in these societies. For instance, the body face in the culture of Japanese is what refers to the dignity a person holds in reference to the social contexts. Face holds to the prestige, honor, and reputation. For this reason, people have a tendency to save the face by taking into lengths to preserve their positions in the society and taking actions to ensure that good reputation is maintained. This has now become a culture that is learned and maintained by all. â€Å"Miner in his works has used a number of examples which in a real sense, have their common names. For instance, Notgnishaw, the Pa-To-Mac, and the cherry tree with the Spirit of Truth is the fact that America lies between Mexico and Canada. Shrines with a chest in the wall or with a box, are the bathrooms which have medicine cabinets. The medicine men are the doctors while the secret language or the ancient code represents the joke that the doctor has an illegible handwriting particular on the prescriptions. The herbalist represents the pharmacist, the substantial gift represents the prescriptions high prices, the font represents the sink, the holy water remains to be the holy water, while the holy mouth men are the dentist. The ritual ablution of the mouth of children is in a real sense, whenever they say something wrong clean their mouths out with soap. Certain magical powders and the small bundle of hog hairs is the toothpaste and the toothbrush. The highly formalized series of gestures is the brushing teeth. On the other hand, men lacerating and scraping the surface of the face with an instrument that is sharp is the act of shaving. The fact that for about one hour women bake their heads in small ovens is the old fashioned hair dryer at the beauty of a salon while the latipsoh is the hospital. Group of vestal maidens and thaumaturge is the nurses and doctor. The magic wands in the supplicant’s mouth are the thermometer while the listener is the psychologist. The limiting of intercourse to certain phases of the moon is the birth control pills while the phrases in the story are the true meaning (Horace, 1956, pg. 503-507).† In a nutshell, certain practices which hold a base on for instance the native aesthetics have a dependency in the natural body and the functions it plays. The ritual life of Nacirema is a clear evidence of this. Miner most words have a common name, for instance, the Notgnishaw, the Pa-To-Mac, and the cherry tree with the Spirit of Truth which means that America lies between Mexico and Canada among others. I am in agreement with Miner that our culture?s primary focus is the body. Furthermore, In understanding the Horace Miner?s ?Body ritual among the Nacirema†, one will note that the Nacirema culture is one that is characterized by a market economy that is highly developed. The market economy has evolved to a rich natural habitat. It is seen that a lot of time is spent by people in the economic devoted pursuits. However, a large number of the activities and part of days are being spent in the ritual related activities that focus on the body as discussed in the above paragraphs.

Indirect Question Definition and Examples

Mathematics Ever Since Elementary School - 992 Words

I have struggled with mathematics ever since elementary school. I could never understand mathematical concepts or apply them to realistic situations. Solving similar equations repeatedly seemed tedious to me and I did not have the patience for it. Since I have been better in English and acquired an interest for it from a young age, I was always told the ignorant idea that people who thrive in english, often struggle in math. Despite knowing that this belief was untrue, I always depended on it as an excuse for my deficiency in math. Even when I would understand the order of completing an equation, I would often make slight errors throughout the process, which was discouraging. My homework assignments and tests received low scores because of my inability to remember every detail to solve the problems correctly. That became my perspective towards math as a whole, a problem that I could not solve. As a young child, I always assumed that tests were the only accurate measure of my ability in math because of my elementary school’s emphasis on standardized state assessments. I thought these scores would determine not only my capability in math but also my potential for future math courses. Although I did try to be attentive in class, I did not comprehend most of the materials being taught and I struggled through these assessments. Upon receiving our official scores, I was always ashamed to compare scores with classmates as the majority of them excelled in math. I completedShow MoreRelatedThe Mathematics Of Math Education929 Words   |  4 Pagesa daily basis in our everyday life. â€Å"Mathematics is the queen of science, and arithmetic the queen of mathematics† (Carl Friedrich Gauss). Not only is math a tremendous part of everyday life but it is also a substantial part of education. 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The Causes Of The Civil War (1488 words) Essay Example For Students

The Causes Of The Civil War (1488 words) Essay The Causes Of The Civil WarThe Political WarThe North and South fought over politics, mainly the idea of slavery. Basically the South wanted and needed it and the North did not want it at all. The South was going to do anything they could to keep it. This was the issue that overshadowed all others. At this time the labor force in the South had about 4 million slaves. These slaves were very valuable to the slaveholding planter class. They were a huge investment to Southerners and if taken away, could mean massive losses to everyone. Slaves were used in the South as helpers in the fields in the cultivation of tobacco, rice, and indigo, as well as many other jobs. The South especially needed more slaves at this time because they were now growing more cotton then ever because of the invention of the cotton gin. Cotton production with slaves jumped from 178,000 bales in 1810 to over 3,841,000 bales in 1860. Within that time period of 50 years the number of slaves also rose from about 1,19 0,000 to over 4,000,000. The plantation owners in the South could not understand why the North wanted slavery abolished that bad. Southerners compared it with the wage-slave system of the North. They said that the slaves were better cared for then the free factory workers in the North. Southerners said that slave owners provided shelter, food, care, and regulation for a race unable to compete in the modern world without proper training. . But after the American Revolution slavery really died it the North, just as it was becoming more popular in the South. By the time of 1804 seven of the northern most states had abolished slavery. During this time a surge of democratic reform swept the North and West. There were demands for political equality. The South felt these views were not important. All of these views eventually led to an attack on the slavery system in the South, and showed opposition to its spread into whatever new territories that were acquired. Northerners said that slave ry revoked the human right of being a free person. Now with all these views the North set out on its quest for the complete abolition of slavery. When new territories became available in the West the South wanted to expand and use slavery in the newly acquired territories. But the North opposed to this and wanted to stop the extension of slavery into new territories. The North wanted to limit the number of slave states in the Union. But many Southerners felt that a government dominated by free states could endanger existing slaveholdings. The South wanted to protect their states rights. The first evidence of the North’s actions came in 1819 when Missouri asked to be admitted to the Union as a slave state. After months of discussion Congress passed the Missouri Compromise of 1820. This compromise was legislative measures that regulated the extension of slavery in the United States for three decades. Now the balance of 11 free states and 11 slave states was in trouble. Maine also applied for statehood in 1819, in which it was admitted as a free state. To please the South, slavery would be prohibited forever from Louisiana Purchase territories north of 36? 30. Southern extremists opposed any limit on the extension of slavery, but settled for now. Missouri and Maine were to enter statehood simultaneously to preserve sectional equality in the Senate. For almost a generation this Compromise seemed to settle the conflict between the North and South. But in 1848 the Union acquired a huge piece of territory from Mexico. This opened new opportunities for the spread of slavery for Southerners. But the distribution of these lands in small lots speeded the development of this section, but it was disliked in the South because it aided the free farmer more than the slaveholding plantation owner. So now Congress passed the Compromise of 1850. It dealt mainly with the question of whether slavery was to be allowed or prohibited in the regions acquired from Mexico as a result of the Mexican War. This compromise allowed abolition of the slave trade in the District of Columbia and admission of California as a free sta te. Another part of the compromise was the Fugitive Slave Law of 1850, which provided for the return of runaway slaves to their masters. But many free states in the Union passed personal liberty laws in an effort to help the slaves escape. Many Northerners set up underground railroads where the runaway slaves could hide and get food and be directed to Canada for freedom. This angered many Southerners. This compromise also said that the territory east of California given to the United States by Mexico was divided into the territories of New Mexico and Utah, and they were opened to settlement by both slaveholders and antislavery settlers. This measure outdated the Missouri Compromise of 1820. All these compromise measures resulted in a gradual intensification of the hostility between the slave and free states. Again another law was passed in 1854. It was called the Kansas-Nebraska Act. It authorized the creation of Kansas and Nebraska. It repealed the Missouri Compromise of 1820 that had prohibited slavery in the territories north of 36? 30, and stated that the inhabitants of the territories should decide for themselves the legality of slaveholding. The removal of the restriction on the expansion of slavery ensured southern support for the bill, which was signed into law by President Franklin Pierce on May 30, 1854. A conflict developed in Kansas between proslavery settlers from Missouri and antislavery newcomers who began to move into the territory from the northeastern states. This was what known as Bleeding Kansas. There were also many people in the North known as abolitionists who made the South look very bad. The abolitionists played a major role in shaping the views of many Northerners. These people were fully against slavery and its expansion and most of the time took matters into their own hands to get their point across. .ua91b2345b99390d6c5bfdb4c520aaf95 , .ua91b2345b99390d6c5bfdb4c520aaf95 .postImageUrl , .ua91b2345b99390d6c5bfdb4c520aaf95 .centered-text-area { min-height: 80px; position: relative; } .ua91b2345b99390d6c5bfdb4c520aaf95 , .ua91b2345b99390d6c5bfdb4c520aaf95:hover , .ua91b2345b99390d6c5bfdb4c520aaf95:visited , .ua91b2345b99390d6c5bfdb4c520aaf95:active { border:0!important; } .ua91b2345b99390d6c5bfdb4c520aaf95 .clearfix:after { content: ""; display: table; clear: both; } .ua91b2345b99390d6c5bfdb4c520aaf95 { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .ua91b2345b99390d6c5bfdb4c520aaf95:active , .ua91b2345b99390d6c5bfdb4c520aaf95:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .ua91b2345b99390d6c5bfdb4c520aaf95 .centered-text-area { width: 100%; position: relative ; } .ua91b2345b99390d6c5bfdb4c520aaf95 .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .ua91b2345b99390d6c5bfdb4c520aaf95 .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .ua91b2345b99390d6c5bfdb4c520aaf95 .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .ua91b2345b99390d6c5bfdb4c520aaf95:hover .ctaButton { background-color: #34495E!important; } .ua91b2345b99390d6c5bfdb4c520aaf95 .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .ua91b2345b99390d6c5bfdb4c520aaf95 .ua91b2345b99390d6c5bfdb4c520aaf95-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .ua91b2345b99390d6c5bfdb4c520aaf95:after { content: ""; display: block; clear: both; } READ: The Road Not Taken EssayThe last main conflict that led to succession was during the presidential election of 1860. The newly formed Republican Party nominated Abraham Lincoln on principles that opposed the further expansion of slavery. Now with Lincoln being elected the South really felt that expansionism was being threatened, and because expansion was vital to the survival of slavery they also felt their way of life was being threatened. Because slavery was such an important part of Southern society, the South felt that they could not survive without it. Now they felt there was nothing more they could do. They were convinced that they should make a bid for independence b y succeeding rather then face political encirclement. This was officially the end and now the South wanted to succeed. Lincoln said that succession was illegal and said that he intended to maintain federal possessions in the South. Southerners hoped the threat of succession would force acceptance of Southern demands, but it did not. Finally the day came on Dec. 20, 1860 when South Carolina adopted an ordinance of succession. The other states to follow and succeed were: Mississippi on Jan 9, 1861, Florida on January 10, Alabama on Jan 11, Georgia on January 19, Louisiana on January 26, and Texas on February 1. On February 4 delegates from all these states met in Montgomery, Alabama where they drafted a constitution for the Confederate States of America. This outraged the North and what was led to the Civil War. Many different efforts were made to save the Union and prevent a war. James Buchanan believed the Constitution did not allow the North to take any action against the South. An effort was made on February 4th by the Virginia Legislature who called a conference of the states at Washington D.C. Representatives were sent from 7 slave and 14 free states. An amendment was passed saying Congress could never interfere with slavery in the states. But it was not ratified by the necessary number of states and was forgotten when the Civil War began. The existence of slavery was the central element of the conflict between the North and South. Other problems existed that led to succession but none were as big as the slavery issue. The only way to avoid the war was to abolish slavery but this could not be done because slavery is what kept the South running. But when the South seceded it was said by Abraham Lincoln A house divided against itself cannot stand. I believe this government cannot endure permanently half slave and half free. Because slavery formed two opposing societies, and slavery could never be abolished, the Civil War was inevitable. These were all the reasons why the Civil War was fought over political beliefs and the North and South had totally opposing views. American History

Joints and Body Movements Essay Example

Joints and Body Movements Paper Purpose: What is the purpose of this exercise? In this exercise I will exam how joints function and thereby discover how they allow for movement in the body. Joints are where two bones come together. The joints hold the bones together and allow for movement of the skeleton. All of the bones, except the hyoid bone in the neck, form a joint. Joints are often categorized by the amount of motion they allow. Some of the joints are fixed, like those in the skull, allow for no movement. Other joints, like those between the vertebrae of the spine, allow for some movement. Most of the joints are free moving synovial joints. In this exercise I will exam how joints function and thereby discover how they allow for movement in the body. Are there any safety concerns associated with this exercise? If so, list what they are and what precautions should be taken. Basic lab precautions, including keep a clean workspace and washing your hand when dealing with raw poultry. In order to ensure that this occurs layout the equipment beforehand in a clean sterile environment and follow safe work practices. Exercise 1: Questions A. As you observe the skull, explain how the structure of the sutures between the cranial bones is related to the overall function of the cranium. We will write a custom essay sample on Joints and Body Movements specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Joints and Body Movements specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Joints and Body Movements specifically for you FOR ONLY $16.38 $13.9/page Hire Writer Children’s heads needs to squeeze through the birth canal during delivery, humans during infancy have evolved with a soft skull composed of many different bony plates that meet at regions called cranial sutures. These sutures also allow the skull to grow rapidly during the first year of life, at which time the bones start to slowly fuse together. This allows the skull to continue to protect the skull during early development. B. Why are synarthroses an important component of fibrous joints? These joints are weight bearing and the joints provide stability and cushioning. Synarthrotic joint is to provide a stable union between bony surfaces. The suture and synchondrosis actually become more stable when ossification of the joint takes place. Exercise 2: Questions A. Cartilaginous joints exhibit amphiarthroses. Why is this important? Amphiarthroses provides an articulation between bony surfaces that permits limited motion and is connected by ligaments or elastic cartilage, such as that between the vertebrae. B. Structurally, how are cartilaginous joints similar? Cartilaginous joints are connected entirely by cartilage. Cartilaginous joints allow more movement between bones than a fibrous joint but less than the highly mobile synovial joint. Cartilaginous joints also form the growth regions of immature long bones and the intervertebral discs of the spinal column. Exercise 3: Questions A. Which type of synovial joint has the least amount of movement? Plane joints permit sliding or gliding movements in the plane of articular surfaces. The opposed surfaces of the bones are flat or almost fat, with movement limited by their tight joint capsules. B. Why are diarthroses important for synovial joints? Diarthrosis permits a variety of movements. All diarthrosis joints are synovial joints and the terms diarthrosis and synovial joint are considered equivalent. C. Which synovial joint is most movable? A ball and socket joint is a joint in which the distal bone is capable of motion around an indefinite number of axes, which have one common center. It enables the bone to move in a 360Â ° angle. D. What are the four structural characteristics that all synovial joints share? Synovial joints all have synovial fluid, articular cartilage, articular capsule, synovial membrane, capsular ligaments, blood vessels, and sensory nerves. Exercise 4: Questions A. Which of the body movements was the most difficult to perform? Why? Inversion which is a gliding joint and provides little movement. B. Hinge joints like the elbow and knee have limited movement. Why are these types of joints more prone to injury? Hinge joints in the elbow and knee contain a lot of anatomical structures packed into a tiny space and when challenged with heavy and constant use, it thus especially prone to injury and infection. C. When performing flexion on the arm, the biceps muscle (on the anterior of the arm) contracts. What happens to the triceps muscle (on the posterior of the arm) as this action is performed? As you perform flexion on your arm the triceps muscle relaxes. D. Both the shoulder and the hip are ball and socket joints. Why does the shoulder have a greater range of motion than the hip? The muscles and joints of the shoulder allow it to move through a remarkable range of motion, making it the most mobile joint in the human body. The shoulder can abduct, adduct rotate, be raised in front of and behind the torso and move through a full 360Â ° in the sagittal plane. Exercise 5: Observations Sketch your chicken wing: Label the bones, muscles, tendons and joints. Exercise 5: Questions A. What effect will the tearing of a tendon have on its corresponding muscle? The corresponding muscle will shrink due to the decreased activity tendon. This is because when the tendon is torn the area around the tendon will not be in very much use until the tendon is repaired which can take a good while unless professionally handled. The muscle will go back to its original size once the tendon heals and the muscle is used more. B. Why are ligaments harder to heal than tendons? Tendons heal faster than ligaments. The reason is that tendons are connected to the muscle, which will allow them to receive a larger blood flow. Ligaments are connected to bone which supplies less blood. Blood is the key -what carries nutrients in order to repair the tissue. C. Compare and contrast tendons and ligaments. Ligaments connect bone to bone and tendons connect bone to muscle. D. What is the function of fascia? It is responsible for maintaining structural, provides support and protection, and acts as a shock absorber. The function of muscle fasciae is to reduce friction to minimize the reduction of muscular force. Fasciae: a) Provide a sliding and gliding environment for muscles. b)Suspend organs in their proper place. c) Transmit movement from muscles to bones, and d) Provide a supportive and movable wrapping for nerves and blood vessels as they pass through and between muscles. [ E. What effect would the loss of articular cartilage have on a joint, its bones and their corresponding muscles? It causes the breakdown of the cartilage in joints. It also called degenerative arthritis. Cartilage is the joints cushion. It covers the ends of bones and allows free movement. If it becomes rough, frays, or wears away, bones grind against each other. As a result, the joint becomes irritated and inflamed. Sometimes the irritation causes abnormal bone growths, called spurs, which increase swelling. Conclusions Explain how skin, bones, and muscles are related to each other. Why is this relationship important to the understanding of the skeletal and muscular systems? Joints are where two bones come together. The joints hold the bones together and allow for movement of the skeleton. All of the bones, except the hyoid bone in the neck, form a joint. Joints are often categorized by the amount of motion they allow. Some of the joints are fixed, like those in the skull, allow for no movement. Other joints, like those between the vertebrae of the spine, allow for some movement. Most of the joints are free moving synovial joints.

Cover Critique #1 with Mark Ecob

Cover Critique #1 with Mark Ecob Cover Critique #1 with Mark Ecob We are very excited to bring you the highlights from our first  Reedsy Live Chat, which as promised will be a regular feature in the coming months.  Every live chat features one professional from the Reedsy marketplace hosting an interactive session that includes among other things free advice on topics like editing, book design, and marketing.We started things off with our first Cover Critique, a big thanks to the terrific Mark Ecob for an informative session.Mark runs his own design studio  and specialises in book cover design. He has worked with large publishing houses like  Penguin, Little, Brown and Amazon, as well as independents such as Faber and Icon. Since 2012 he has been Associate Art Director for Unbound, the London based crowd-funding publisher.  His work has been recognised three times by the Design Art Directors Association (DAD), and exhibited at the Hay Literary Festival 2012.For those of you who missed it, we've compiled a brief recap. However, we strongl y recommend you watch the videos. And if you want to take part in our next Cover Critique, with Jake Clark, remember to send your covers in advance to covers@reedsy.com.Cover Critique  with Mark Ecob - Part 1Just click on the image below to watch the video!

Love Using specific artistic examples define Neoclassicism Essay

Love Using specific artistic examples define Neoclassicism - Essay Example To a certain extent, the assertion that neoclassicism was a representation of a reaction against optimistic, energetic, and passionate renaissance view could be true. This view perceived man as a being fundamentally good, with an infinite potential for both spiritual and intellectual growth. However, theorists of neoclassical view considered man as imperfect and inherently sinful, with a limited potential. The renaissance view gave facts from imagination, invention, and experimenting, but was replaced by neoclassical view. This view gave emphasis on order and reason, on common sense, on restraint, and on religious, economic, philosophical, and political conservatism. A famous neoclassical painter Jean-Auguste-Dominique Igres, who lived from 1780 to 1867 made outstanding paintings (154). One of his paintings, The Apotheosis of Homer, which symbolizes the belief of Ingres in a hierarchy of timeless, is a good example since it based its work on classical precedent. Baron Pierre-Narcisse Guerin is also a famous French artist of the neoclassical period who made a painting known as Aurora and Cephalus and appears as shown below. In essence, neoclassicism concentrated on the fact that man was the most accurate subject of art, perceiving art as fundamentally pragmatic. In addition, to the theorists, art was valuable since it was useful, and properly intellectual, but not emotional (198). The main aim of neoclassical was to substitute overall design with the new ideas of symmetry, proportion and the like. In literary forms, they gave emphasis on essays, letters, satire, and such. Though neoclassicism seemed replaced later, it is work noting that artistic movements do not really die. This is evident because aesthetics of neoclassicism reappeared later in the 20th

Business - Affirmative Action Research Paper Example | Topics and Well Written Essays - 1750 words

Business - Affirmative Action - Research Paper Example It is an act to increase the representation of minority by giving them preference on the basis of gender, color, origin, sexual orientation etc. Moreover, this act is also done to increase the participation of the under representative part of the society to showcase what they are capable of. Historical Background: General Background History The term ‘affirmative action’ was first used in 1935 in a National Labor Relations Act (29 U.S.C.  §Ã‚ §151–169). The usage for it was not for race but to provide remedy for employers to avoid discrimination of union members. However, in books the origin of this term was mentioned to root from the United States. During the presidency of John F. Kennedy, it first appeared in Executive Order 10925 and it was signed by the President on March 6th 1961 (Jain and Ratnam). It was used to refer to methods used to achieve non-discrimination policy implementation. In 1965, Executive Order 11246 was issued by the President Lyndon Johnso n which stated that federal contractors should use affirmative action to avoid discrimination while employing a person. Hiring should be made irrespective of race, religion and national origin. The 1964 Civil Rights Act implemented this clause that no race discrimination by statute should be carried at the workplace. Title II of 1964 act stopped places which were public, such as restaurants or hotels from discriminating on the basis of race. Gradually in 1968, gender was also added to the list. Purpose of Affirmative Action Since the Civil Rights Movement, much has been changed in a positive manner and a great contribution to it was the introduction of Affirmative action. This attempt was to achieve a better and more equal society. It was started as a ‘Corrective measure for societal and governmental discriminations against groups that have been at a disadvantage and subject to prejudices’. However, much has changed since its inception. Supporters of Affirmative Actionà ‚   There are many people, organizations and societies supporting the inherent goodness of affirmative action. Some of them are given below: According to a report published in 2007 by Pew Research Center, support for affirmative action in the American public has increased to 70% in 2007 compared to 58% in 1995. The US Military is another endorser of affirmative action. In 2003, many high ranking officers of Army, Navy, Air force and Marine Corps planned a rally in support of affirmative action for a Supreme Court case Grutter v. Bollinger. The fortune 500 companies have been a popular endorser of affirmative action. More than 60 leading companies in fortune 500 which encompasses 3M, GE, HP, Kraft Foods, Coca-Cola came out for the support of affirmative action in 2003. Universities have been a popular supporter of affirmative action. Harvard University, University of Chicago, University of Pennsylvania, Yale University and Dartmouth College provided their support for race-conscious a dmission programs. They wanted to promote diversity in all forms and, therefore, in 2003 they showed their popular support for it. Popular athletes are endorsers of affirmative action. Many of the Michigan’s leading sports athlete including Tom Izzo (Michigan State University), Joanne P. McCallie (Michigan State University), Tommy Amaker (University of Michigan) and Ernie Zeigler (Central Michigan University) spoke about the importance of affirmative ac

Airborne infectious disease

Airborne infectious disease Tuberculosis (TB) is an airborne infectious disease which is caused by bacteria belonging to Mycobacterium tuberculosis complex1. There are approximately one third of the worlds population are infected with tuberculosis where nine millions of new cases reported annually2. Although tuberculosis is essentially curable and preventable, it continues to cause millions of deaths every year2. When infected individual coughs, sneezes or spits, M. tuberculosis is propelled into the air and infected those who breathed in the bacteria that existed in droplets of saliva3. Primarily, tuberculosis will affect the lungs, known as pulmonary tuberculosis3. It will also affect other parts of body, for instance lymph nodes, bones, brain and kidneys3. Once a person is infected with tuberculosis, there are basically three possible ways may occur. Firstly, the immune system plays a vital role and strong enough to kill the bacteria3. Secondly, immune system is not strong enough to fight off the bacteria bu t is able to build a defensive barrier against the bacteria3. Individuals who are latently infected with M. tuberculosis show asymptomatic where these bacteria lie dormant in the lungs and able to reactivate after years1. The disease is often reactivated in those who are immunocompromised or generally weakened. Lastly, the immune system fails to kill bacteria causing the bacteria to grow and spread towards other parts of body which is called active tuberculosis3. In the fight of tuberculosis, World Health Organisation (WHO) recommends universal Bacille Calmette-Guà ©rin (BCG) vaccination in the countries with high TB burdens4. BCG vaccine contains weakened form of M. tuberculosiswhich will induce antibodies to fight against this type of bacteria. The efficacy of BCG vaccination can be ranging from 0% to 84%5. This may be due to the frequency of TB exposure and quality of vaccine used, leading to arguments on BCG vaccination efficacies4. One of the greatest arguments is that BCG vaccination causing positive reactions to tuberculin skin testing and hence interfere with the diagnosis of latent TB4. Existence of evidences showing the rates of efficacy also depends on geographical location, age at vaccination and form of TB further complicate the situation. Currently, TB chemotherapy is made up of a cocktail of first-line drugs isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA) and ethambutol (EMB) 6. If the treatment fails due to bacterial dr ug resistance, or patient unable to tolerate, second-line drugs for instance para-aminosalicylate (PAS), fluoroquinolones, ethionamide and cycloserine are introduced6. These are considered as second line drugs generally either less potent with larger doses or more toxic with serious side effects6. Tuberculosis is presently treated in two phases, namely initial phase and continuous phase7. In initial phase, the patient will be treated with concurrent use of four first line drugs, with the aim to eradicate or control bacteria population to replicate in rapid motion and also avoid the emergence of bacteria resistance7. The treatment choices available for initial treatment include isoniazid, rifampicin, pyrazinamide and ethambutol7. Streptomycin is used rarely but can be used in patients who infected with bacteria that are resistant to isoniazid before the therapy is commenced7. The duration for initial phase is 2 months whereas the continuous phase takes 4 months7. During the four months of continuous phase, patients are treated with isoniazid and rifampicin at same doses7. Most of the TB treatment is supervised where drug administration needs to be fully supervised by healthcare professions since lengthy duration of treatment causing incompliance in patients7. These patients who are unlikely to be compliance will be given the drugs three times a week until the course is completed while patients who able to comply with the treatment will not be supervised7. Despite the chemotherapy treatment and BCG vaccine, TB remains as a significant infectious disease due to increasing emergence of drug resistant TB and co-infection with Human Immunodeficiency Virus (HIV) 6. Since the host defense in HIV patients is suppressed, they are more susceptible to TB infections. Moreover, drug- drug interactions between antiviral therapy and anti-TB also causing complications in treating co-infected patients6. Drug resistant TB has evolved mainly because of improper treatment or incompliance in patients who stop taking their medications before the bacteria is being fully eradicated since the duration of treatment is lengthy which takes 6-9 months8, 9. The mechanism involved includes chromosomal mutations in genes that responsible for drug targets encoding9. When there is a sequential accumulation of mutations, multi-drug resistant tuberculosis (MDR-TB) emerges where the M. tuberculosis strains will resistant to two of the most commonly used drugs, Isoniazid and Rifampicin9. Patients with MDR-TB are then relying on the second-line drug classes, fluoroquinolones and the three injectable agents namely amikacin, capreomycin, and kanamycin10, 11. The chances to cure would dramatically be reduced for patients who infected with extensively drug-resistant tuberculosis (XDR-TB), a situation where the isolated strains are resistant against any one of fluoroquinolones and at least one of three injectable drugs12. In order to combat with the MDR-TB or XDR-TB and optimize the tuberculosis drug regimen, it is crucial to understand the mechanism of action of current using first-line drugs and how resistance is developed against these drugs. Isoniazid (INH) or isonicotinic acid hydrazide is discovered in 1952, a bactericidal agent which active against organism of the genus Mycobacterium, especially M. tuberculosis, M. bovis and M. kansassi6, 13. In vivo, INH has shown to be bactericidal in culture over the first 48 hours which become bacteriostatic after this particular time frame13. This indicates that INH is bacteriostatic for slow growing or resting bacilli but is bactericidal for rapidly dividing mycobacterium. The minimal tuberculostatic concentration is 0.025 to 0.05ug/ml14. INH is a prodrug that needs to be activated by catalaseperoxide hemoporotein, KatG before acts by inhibiting mycolic acid synthesis and cell wall disruption in susceptible mycobacterium14, 15. This inhibitory action is very specific since mycolic acids are unique to mycobacteria14. INH acts by inhibit enoyl acyl carrier protein (ACP) reductase, InhA, and a beta-ketoacyl-ACP synthase, KasA that are crucial in fatty acid synthesis system for myco lic acid16. Resistance to INH is believed due to mutations in gene encoding catalaseperoxidase katG or InhA or lacking KatG9, 15. Isoniazid is metabolised in the liver, mainly by acetylation and dehydrazination where slow acetylator may experience higher concentration leads to potential toxicity before excreted in the urine within 24 hours14. Rifampicin (RIF), discovered in 1963, is a lipophilic semisynthetic derivative of rifamycin antibiotic which is produced by the fermentation of a strain of Amycolatopsismediterranei6, 9, 17. RIF has bactericidal activities against a broad spectrum of microorganisms including gram-positive and gram-negative. RIF will inhibit the action of DNA-dependent RNA polymerase of mycobacteria that is encoded by rpoB through formation of a stable drug-enzyme complex9. This will suppress the initiation chain formation in RNA synthesis and hence prohibit protein synthesis in M. tuberculosis9. Development of resistance to RIF is mostly due to mutation in 81 base pair region of rpoB gene thus facilitate a straightforward approach to detect MDR-TB since 85-90% RIF-resistant strains are also resistant to INH9. RIF produces peak plasma concentration of 7ug/mL in 2 to 4 hours after ingestion of 600mg18. It also distributed well to most of the body tissues and fluids, including cerebrospinal fluid since it is lipophilic18. Following absorption from the gastrointestinal tract, RIF is eliminated rapidly in the bile with fewer amounts excreted through urine18. Pyrazinamde (PZA) is discovered in 1954 and it produces excellent sterility effects against semidormant tubercle bacilli at slightly acidic pH6, 9. The antimicrobial activity of PZA is through interference with mycolic acid synthesis in M. tuberculosis by pyrazinoic acid, an active moiety of PZA9. Conversion of PZA to pyrazinoic acid is mediated by pyrazinamidase enzyme that is encoded by pncA gene in M. tuberculosis, thus indicating that these bacilli are sensitive to PZA9. Resistance against PZA evolved when mutation occur at pncA gene that is responsible for pyrazinamidase, hence affecting the activity of this enzyme9. PZA is well absorbed from gastrointestinal tract and is widely distributed to most tissues and fluid too18. The oral administration of 500 mg PZA produces plasma concentrations of 9-12ug/ml after two hours and 7ug/ml after 8 hours18. PZA is metabolized in liver whereas the metabolites are excreted through renal glomerular filtration18. Ethambutol (EMB) is discovered in 1962, acts as bacteriostatic agent and is active against undergoing cell division6, 19. EMB primarily targets on impairment of cell wall polymerization by inhibits arabinosy transferase, a vital enzyme responsible for mycobacteria cell wall biosynthesis9, 19. Since arabinosy transferase enzyme is encoded by embC-embA-embB genes, resistance against EMB evolved is believed due to mutation of these genes9. EMB is currently used as one of the first-line treatment for tuberculosis mainly because of its synergistic effect with other front-line drugs and its low toxicity property19. There is roughly 75-80% of an oral dose of EMB is rapidly absorbed in gastrointestinal tract with absorption unaffected when administered with foods20. In addition, EMB is distributed widely to body tissues and fluid, including cerebrospinal fluid before being metabolized in the liver and excreted in urine20. Streptomycin (SM) is an aminoglycoside antibiotic, used as first line treatment for TB when it first discovered in 19441, 6. Streptomycin is isolated from the bacteria Streptomycesgriseus and its antimicrobial effects against M. tuberculosisis highly effective when use in combination with other first line agents21. However, SM is no longer considered as first line treatment as resistance against it has developed rapidly1. The optimum pH for SM is at pH8 where its bacteriostatic activity will reduce with increasingly acidic environment21. SM acts by binding tightly to A site of 16S ribosomal RNA subunit, interferes with mRNA translation, causing faulty protein being produced1, 9. Resistant emergence when the mutation occurs at gene rpsL and rrs that encoded for 16S and S12 ribosomal protein1, 9. Upon administration, SM is poorly absorbed from gastrointestinal tract and mostly administered parentally1. SM is mostly excreted in urine and patients with low renal profile might experience toxicity such as neurotoxic reactions1. When the first line treatment is no longer suitable for patients or patients develop multi-drug resistance TB, second line drugs will then be introduced in combating the TB. Second line drugs that are mostly used include Ethionamide (ETH), Cycloserine (CS), Para-Aminosalicylic Acid (PAS) and Fluoroquinolones (FQ). ETH has been in use since 1960s, is a structural analogue of INH and it targets at inhibition of mycolic acid biosynthesis in tubercle bacilli9, 22. INH however is much more potent than ETH since the minimal inhibitory concentration for ETH is 0.5-5.0ug/mL22. Resistance evolved due to mutation at gene InhAand ethA which encode for oxygenase enzyme in activation of ETH 9. In vitro, CS has inhibitory effect on M. tuberculosis at 5-200ug/mL and there is no cross resistance occurred between CS and other drugs14. CS acts by interfereing the biosynthesis of bacterial cell wall14. CS is well absorbed in gastrointestinal tract and also widely distributed to body tissues and fluid including cerebrospinal fluid14. PAS was first introduced as first line drug but being replaced by Ethambutol in 1960s1. It acts bacteriostatically with possessing inhibitory effect at concentration less than 1mg/ml by interfere with folic acid metabolism in bacteria1. PAS is readily absorbed from gastrointestinal tract and distributed well throughout the body. Approximately 80% of the drugs will be excreted via kidney after being metabolized to acetylated form1. Moxifloxacin and Gatifloxacin are both been synthesized and evaluated as excellent bactericidal agents through inhibiting DNA gyrase, an ATP-dependent enzymes topoisomerase II which is responsible in bacteria DNA transcription9. DNA gyrase is consisted of two subunits that is arranged in a complex, is encoded by two different genes, gyrA and gyrB where mutations at gyrA will normally cause bacteria resistance to these new generation of flouroquinolones9. Due to the increasing incidence of multidrug resistance TB, it is highly desirable to develop new drugs that are not only potent and effective against current resistant strains of M. tuberculosis but also possess shorter treatment duration since most of the incompliance of patients is brought up by lengthy TB treatment. Most of the mechanisms of action of current treatments are involved in interfering the bacterial DNA synthesis, protein and mycolic cell wall biosynthesis. The enzymes that participate in these pathways could also be the target of newly designed drugs such as TMC207, one of the new drugs which are currently under investigations and clinical trials. TMC207 is a member of diarylquinoline class of compound which target at adenosine triphosphate (ATP) synthase by binding to subunit C of the synthase, blocking the energy pathway of mycobacteria23, 24. In vitro, TMC207 not only possesses ability to inhibit both drug sensitive and resistant M. tuberculosis isolates, but also able to sterilize the patient through killing the dormant bacilli bactericidally23. TMC207 showed a minimum inhibitory concentration of 0.03ug/mL against M. tuberculosis, suggesting a more potent agent compared to current first- line treatments such as isoniazid and rifampicin24. Apart from that, its synergistic effect with pyrazinamide could promise as effective drug combination for sterilizing the patients against TB23. A phase I clinical trials which involved short terms administration of TMC207 in healthy individuals showing no adverse effects and the subjects are well tolerated with it24. However, it is essential to investigate the selectivity of TMC207 again st mammalian ATP synthase with longer periods to ensure the patients safety when administered with TMC207. Thiacetazone (TAC) is widely used as second line anti-TB agent against multiresistant tuberculosis at present25. TAC acts by interferes the biosynthesis pathway of mycolic acid in tubercle bacilli25. The fact that M. tuberculosis has been difficult to eradicate and remains persistent is due to its cell wall that composed of mycolic acid which is resistant against chemical injury, dehydration and also has low permeability to antibiotics25. Mycolic acid contains cyclopropane rings that is activated through cyclopropane mycolic acid synthase (CMASs), has a significant contribution to tuberculosis25. By inhibiting the cyclopropanation, the cell wall biosynthesis will then be interrupted, introducing the bactericidal effects25. The aim of this research is to synthesis and evaluates the analogues of Thiacetazone which might be potential anti tuberculosis agents. The analogues will be tested against different strains of mycobacteriain lab. The target actions of these analogues will also be identified based on the structure of the analogues. The above analogue is synthesized when a benzylaldehyde reacts with a primary amine. This is a condensation process and an imine is produced. The changes at position R1 to R3 with different electron withdrawing groups are first planned to be evaluated. However, the plan is prohibited since the corresponding structures are either unavailable or too expensive that falling outside the budget. After revised on the previous analogues that were discovered and their respective MIC values obtained from lab, the structures of new analogues that are going to be evaluated are finally sorted out. The R1 to R3 positions would be replaced by either a -chloro or a -methoxy with R8 position would either be an amine, a methyl or a benzene ring. A chloro is used at position R1 to R3 since it is electron withdrawing, big and lipophilic molecule whereas the methoxy group is electron donating, small and quite lipophilic. For R8 position, an amine is selected because it is electron withdrawing and small. A methyl is also selected since it is quite lipophilic, small and electron donating. On the other hand, benzene ring which is highly lipophilic, neither electron donating nor withdrawing group might have a different effect on the analogue synthesized.

Old Man And The Sea :: essays research papers

In life, one will go through a number of stages in life. Infancy, Youth , Adulthood, and Old Age are all key stages. As one grows, they mature through these various stages. When one reaches old age, there is often a lot of doubt surrounding their lives. Serenity, and independence are often the two most questioned. These are some questions that Santiago has to ask himself as well.   Ã‚  Ã‚  Ã‚  Ã‚  In the novel The Old Man And The Sea, Ernest Hemingway develops the concept of man coming to the realization that as he ages, his dependency on others will increase. The use of metaphor is key in showing how this is indeed true. The struggle with the Tiburon represents the mental struggle that Santiago is having with himself. The Tiburon is also used as a metaphor for Santiago’s life. The boy in the story parallels what Santiago’s life once was.   Ã‚  Ã‚  Ã‚  Ã‚  The struggle with the Tiburon represents the struggle that Santiago is having with himself. The constant struggle makes Santiago realize that he is no longer as young as he thinks he is and he must rely on the help of others. This is shown when Santiago is battling the Tiburon. “ ‘Bad news for you fish’, he said and shifted the line over the sacks that covered his shoulders. He was comfortable, but suffering, although he did not admit to the suffering at all. ‘ I am not religious...but I will say Ten Hail Marys that I should catch this fish’... ‘Hail Mary full of Grace the Lord is with thee. Blessed art thou among women and blessed is the fruit of thy womb, Jesus. Holy Mary, Mother of God pray for us sinners now and at the hour of death, Amen.’ Then he added. ‘ Blessed Virgin, pray for the death of this fish, wonderful as he is.’ '; [ Hemingway 64-65]   Ã‚  Ã‚  Ã‚  Ã‚  This quote shows that the old man is forced to break the rules of sanity and talks to himself as well as the fish which cannot hear him. The old man thinks to himself that the fish is a “ “ God fearing '; fish and by saying the Hail Mary, the fish will give in and let himself be caught. After saying the Hail Mary the Old Man tries to convince himself that his previously hurt hand is okay, when really it is not.   Ã‚  Ã‚  Ã‚  Ã‚  In another part of the story Santiago admits that he is losing his sanity. “He did not want to look at the fish. He knew that half of him had been destroyed '; [Hemingway 114].

“Hamlet” Monologue Analysis Essay

The text to be or not to be by William Shakespeare refers to the paradox of life and death. He starts the poem by questioning himself: is it worth to exist or not, and by existing he is referring to the human ability of thinking; in the sense of: I exist because I can think. This issue is developed throughout the poem were the action of thinking deals with the decision of; should I live or not and it certainly becomes an obstacle to make that decision. In that sense the poem transmits that the innate human quality of thinking is what makes us weak instead of being a useful tool to make right decisions. In other words, despite we can perceive a solution to our problems (death), we are incapable of taking action (committing suicide) because we have the eternal problem of thinking. â€Å"To be or not to be, that is the question† this is the phrase that opens the poem, and in a sense, it is like a synthesis of what the author is going to explain later. He is referring to the verb â€Å"to be† practically the same as â€Å"to exist†. The question is: should I live? And by that he is considering that, by being humans, we have the ability to think. In some sort of way, Shakespeare is leading us to the paradox of life and death were human doubting is crucial in the understanding of the two, so there can be a decision. â€Å"to die, to sleep, No more; and by sleep to say we end the heart ache and the thousand natural shocks that flesh is hair to: it is a consummation devoutly to be wished† He is analyzing death and seeing it as the solution of the life he is living at the moment. In some way, he is confirming that being alive is a constant pain and so death is the unique pathway that would lead him to another life, a painless one. â€Å"Thus the conscience does make cowards of us all, and thus the native hue of resolution is slicked o’er with the pale cast of thought† This is the fragment in which the poem determines the reason why Hamlet haven’t decided yet nor taken action. This is the fragment were Shakespeare blames human thought for it being an obstacle when there is a decision to make, more precisely: human doubting explores the possible consequences of each action we are about to make, and by knowing them, we soon get afraid of our destiny  and of the unknown circumstances that will surrounds us later. Is an outlook to the future that force us to think back constantly. The doubt and the cowardness do not lead us anywhere. The text can be related to my life in the sense that it is the perfect explanation of the reason why we are afraid of making decisions. Every decision is premeditated and that is why we are uncapable of taking action. Besides, I believe that this reasoning of human thought as an obstacle when it comes to make a decision, applies to our daily life; We give up opportunities because we take a long time thinking, and that certainly is a huge obstacle to clarify our minds and make the right determination.

Essay on Causes of the Holocaust - 980 Words

Causes of the Holocaust The Holocaust took place for a number of reasons some of which were long term and others short term. The main reasons are; for centuries Germany had been an anti-Semitic country Jews were used as scapegoats for German problems. Also centuries of Nazi persecution caused the Holocaust in particular 1933 -1939 as well as Adolf Hitler and his racist views which influenced thousands of Germans. The Main reason for the holocaust happening was that Germany had been anti-Semitic for many centuries, and during those centuries the anti-Semitism had gradually got worse. Therefore because this was becoming a racial war, this was an opportunity for Germany to cleanse†¦show more content†¦In the 1930s the Wall Street crash occurred and the Jews having an image of being well educated and very wealthy and selfish due to all their large important businesses they ran in Germany. Hitler portrayed an image of the Jews to the Germans as though the reason why some Germans are out of jobs is because the Jews have stolen their jobs and are invading Germany being parasites and taking what belongs to pure hardworking German people. Therefore when the economic situation in Germany was very low and the German economy was suffering from the depression, the Jews were blamed for having all the German money and for Germans being very poor and starving during the time of the depression in the 1930s. Despite the fact the Jewish people were not particularly communist at all, due to Hitler being anti- communist, this was another act of using them as scapegoats. Anti - Semitism had been current in Europe for centuries, even since the days of Christ. Other religions blamed the Jews for Christs resurrection and were regarded as Christ killers. As years and centuries have gone by, the Jews were still being blamed for unfortunate events that there wasnt even evidence for. Thirdly I would like to add that there had been centuries of persecution from the Nazis in particular; 1933-1939. In 1933Show MoreRelatedThe Holocaust : The Causes Of The Holocaust804 Words   |  4 PagesAfter WW2, there was a thing called the holocaust. There were many concentration camps all over Germany where many Jews were killed in different ways. It happened between WW1 and WW2, 1933-1945. My position on why this happened is that Germany was going through a rough time, so Hitler wanted their country to resemble power. Read on to learn more about the causes and ways the Holocaust could have been avoided. The Holocaust was a mass slaying of groups of people which that Germany saw as inferiorRead MoreThe Causes Of The Holocaust1352 Words   |  6 PagesIn learning about the Holocaust I have found that the causes of the Holocaust are just as important as the injustice itself. There are many reasons the Holocaust was allowed to happen and many reasons it had become inevitable. 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Th e Holocaust being one of the many genocides in our history was indeed influenced by an intense dislike. That intense dislike was towards certain types of people it ended up taking multiple lives. One of the many races that were hated, and killed during the Holocaust were the Jews. Jews had an average life before the Holocaust. According to the United States Holocaust Memorial Museum website, in 1933, there were about ten million JewsRead MoreThe Cause And Effect Of The Holocaust1811 Words   |  8 Pages2015 The Cause and Effect of the Holocaust Throughout the endless history, there were lots of important and influential event. For example the Dark Age, Enlightenment, Civil War, World War I and II and the Cold War. Over all of these event, there was one event that deeply influence the world and the Jews today, it was the Holocaust. Holocaust, a term that people use to describe the horrible event that happened during World War II which kill millions of innocent citizens. The Holocaust started atRead MoreEssay on Causes Effects of the Holocaust1422 Words   |  6 PagesCauses Effects of the Holocaust There are times in history when desperate people plagued by desperate situations blindly give evil men power. These men, once given power, have only their own evil agendas to carry out. The Holocaust was the result of one such mans agenda. In short simplicity, shear terror, brutality, inhumanity, injustice, irresponsibility, immorality, stupidity, hatred, and pure evil are but a few words to describe the Holocaust. A holocaust is defined as a disaster thatRead MoreEssay about Possible Causes of the Holocaust1903 Words   |  8 PagesMost of the world will no longer deny the mass murder of millions of Jews during World War II (1939-1945). The Holocaust is not a secret anymore. But was the Holocaust the brainchild of a deviant individual or was it an event that came only out of necessity? Was the Shoah intentional or was it functional? Or will we ever know for sure? The answer to that question is no, at least not presently. Historians searching for answers to the question of how the murder of a nation came about are oftenRead MoreThe Holocaust : Its Causes And How It Was Carried Out1497 Words   |  6 PagesDestiny Corbitt Shawn Underell The Holocaust 21 February 2016 The Holocaust The holocaust is one of the memorable events in history and it is important to know some of its causes and how it was carried out. The Holocaust is a controlled torture that killed roughly six million Jews by the Nazi government, led by Adolf Hitler. Apart from the Jews, other groups considered inferior or anti-establishment such as Poles, Romans and gypsies were also killed. There were several reasons for these grisly murdersRead MoreThe Holocaust was the genocide and the cause of death for about 6 million Jews during World War II.800 Words   |  4 PagesThe Holocaust was the genocide and the cause of death for about 6 million Jews during World War II. The Holocaust affected many, including Gypsies, homosexuals, mentally and physically disabled, and anyone who did not fit the description of Hitler’s â€Å"master race†. Hitler was an anti-Semitist who believed in a superior race and killed many Jewish people by putting them in concentration camps. Adolf Hitler was born in Austria on April 20, 1889 to Alois Hitler and Klara Polzl. He was the 4th out ofRead MoreThe Legacy Of The Holocaust859 Words   |  4 Pages As Nobel Laureate Elie Wiesel once said, â€Å"To forget a Holocaust is to kill twice,† that is why we are called to remember. Many movies, novels, and story representations of the Holocaust have been created in order to spread the memory of the past. An important part of remembering is learning, and therefore not repeating the same mistakes once again. Movies may find it difficult to represent the Holocaust accurately, while also giving it meaning and artistic expression. The writer, Edwin de Vries