Airborne infectious disease

Airborne infectious disease Tuberculosis (TB) is an airborne infectious disease which is caused by bacteria belonging to Mycobacterium tuberculosis complex1. There are approximately one third of the worlds population are infected with tuberculosis where nine millions of new cases reported annually2. Although tuberculosis is essentially curable and preventable, it continues to cause millions of deaths every year2. When infected individual coughs, sneezes or spits, M. tuberculosis is propelled into the air and infected those who breathed in the bacteria that existed in droplets of saliva3. Primarily, tuberculosis will affect the lungs, known as pulmonary tuberculosis3. It will also affect other parts of body, for instance lymph nodes, bones, brain and kidneys3. Once a person is infected with tuberculosis, there are basically three possible ways may occur. Firstly, the immune system plays a vital role and strong enough to kill the bacteria3. Secondly, immune system is not strong enough to fight off the bacteria bu t is able to build a defensive barrier against the bacteria3. Individuals who are latently infected with M. tuberculosis show asymptomatic where these bacteria lie dormant in the lungs and able to reactivate after years1. The disease is often reactivated in those who are immunocompromised or generally weakened. Lastly, the immune system fails to kill bacteria causing the bacteria to grow and spread towards other parts of body which is called active tuberculosis3. In the fight of tuberculosis, World Health Organisation (WHO) recommends universal Bacille Calmette-Guà ©rin (BCG) vaccination in the countries with high TB burdens4. BCG vaccine contains weakened form of M. tuberculosiswhich will induce antibodies to fight against this type of bacteria. The efficacy of BCG vaccination can be ranging from 0% to 84%5. This may be due to the frequency of TB exposure and quality of vaccine used, leading to arguments on BCG vaccination efficacies4. One of the greatest arguments is that BCG vaccination causing positive reactions to tuberculin skin testing and hence interfere with the diagnosis of latent TB4. Existence of evidences showing the rates of efficacy also depends on geographical location, age at vaccination and form of TB further complicate the situation. Currently, TB chemotherapy is made up of a cocktail of first-line drugs isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA) and ethambutol (EMB) 6. If the treatment fails due to bacterial dr ug resistance, or patient unable to tolerate, second-line drugs for instance para-aminosalicylate (PAS), fluoroquinolones, ethionamide and cycloserine are introduced6. These are considered as second line drugs generally either less potent with larger doses or more toxic with serious side effects6. Tuberculosis is presently treated in two phases, namely initial phase and continuous phase7. In initial phase, the patient will be treated with concurrent use of four first line drugs, with the aim to eradicate or control bacteria population to replicate in rapid motion and also avoid the emergence of bacteria resistance7. The treatment choices available for initial treatment include isoniazid, rifampicin, pyrazinamide and ethambutol7. Streptomycin is used rarely but can be used in patients who infected with bacteria that are resistant to isoniazid before the therapy is commenced7. The duration for initial phase is 2 months whereas the continuous phase takes 4 months7. During the four months of continuous phase, patients are treated with isoniazid and rifampicin at same doses7. Most of the TB treatment is supervised where drug administration needs to be fully supervised by healthcare professions since lengthy duration of treatment causing incompliance in patients7. These patients who are unlikely to be compliance will be given the drugs three times a week until the course is completed while patients who able to comply with the treatment will not be supervised7. Despite the chemotherapy treatment and BCG vaccine, TB remains as a significant infectious disease due to increasing emergence of drug resistant TB and co-infection with Human Immunodeficiency Virus (HIV) 6. Since the host defense in HIV patients is suppressed, they are more susceptible to TB infections. Moreover, drug- drug interactions between antiviral therapy and anti-TB also causing complications in treating co-infected patients6. Drug resistant TB has evolved mainly because of improper treatment or incompliance in patients who stop taking their medications before the bacteria is being fully eradicated since the duration of treatment is lengthy which takes 6-9 months8, 9. The mechanism involved includes chromosomal mutations in genes that responsible for drug targets encoding9. When there is a sequential accumulation of mutations, multi-drug resistant tuberculosis (MDR-TB) emerges where the M. tuberculosis strains will resistant to two of the most commonly used drugs, Isoniazid and Rifampicin9. Patients with MDR-TB are then relying on the second-line drug classes, fluoroquinolones and the three injectable agents namely amikacin, capreomycin, and kanamycin10, 11. The chances to cure would dramatically be reduced for patients who infected with extensively drug-resistant tuberculosis (XDR-TB), a situation where the isolated strains are resistant against any one of fluoroquinolones and at least one of three injectable drugs12. In order to combat with the MDR-TB or XDR-TB and optimize the tuberculosis drug regimen, it is crucial to understand the mechanism of action of current using first-line drugs and how resistance is developed against these drugs. Isoniazid (INH) or isonicotinic acid hydrazide is discovered in 1952, a bactericidal agent which active against organism of the genus Mycobacterium, especially M. tuberculosis, M. bovis and M. kansassi6, 13. In vivo, INH has shown to be bactericidal in culture over the first 48 hours which become bacteriostatic after this particular time frame13. This indicates that INH is bacteriostatic for slow growing or resting bacilli but is bactericidal for rapidly dividing mycobacterium. The minimal tuberculostatic concentration is 0.025 to 0.05ug/ml14. INH is a prodrug that needs to be activated by catalaseperoxide hemoporotein, KatG before acts by inhibiting mycolic acid synthesis and cell wall disruption in susceptible mycobacterium14, 15. This inhibitory action is very specific since mycolic acids are unique to mycobacteria14. INH acts by inhibit enoyl acyl carrier protein (ACP) reductase, InhA, and a beta-ketoacyl-ACP synthase, KasA that are crucial in fatty acid synthesis system for myco lic acid16. Resistance to INH is believed due to mutations in gene encoding catalaseperoxidase katG or InhA or lacking KatG9, 15. Isoniazid is metabolised in the liver, mainly by acetylation and dehydrazination where slow acetylator may experience higher concentration leads to potential toxicity before excreted in the urine within 24 hours14. Rifampicin (RIF), discovered in 1963, is a lipophilic semisynthetic derivative of rifamycin antibiotic which is produced by the fermentation of a strain of Amycolatopsismediterranei6, 9, 17. RIF has bactericidal activities against a broad spectrum of microorganisms including gram-positive and gram-negative. RIF will inhibit the action of DNA-dependent RNA polymerase of mycobacteria that is encoded by rpoB through formation of a stable drug-enzyme complex9. This will suppress the initiation chain formation in RNA synthesis and hence prohibit protein synthesis in M. tuberculosis9. Development of resistance to RIF is mostly due to mutation in 81 base pair region of rpoB gene thus facilitate a straightforward approach to detect MDR-TB since 85-90% RIF-resistant strains are also resistant to INH9. RIF produces peak plasma concentration of 7ug/mL in 2 to 4 hours after ingestion of 600mg18. It also distributed well to most of the body tissues and fluids, including cerebrospinal fluid since it is lipophilic18. Following absorption from the gastrointestinal tract, RIF is eliminated rapidly in the bile with fewer amounts excreted through urine18. Pyrazinamde (PZA) is discovered in 1954 and it produces excellent sterility effects against semidormant tubercle bacilli at slightly acidic pH6, 9. The antimicrobial activity of PZA is through interference with mycolic acid synthesis in M. tuberculosis by pyrazinoic acid, an active moiety of PZA9. Conversion of PZA to pyrazinoic acid is mediated by pyrazinamidase enzyme that is encoded by pncA gene in M. tuberculosis, thus indicating that these bacilli are sensitive to PZA9. Resistance against PZA evolved when mutation occur at pncA gene that is responsible for pyrazinamidase, hence affecting the activity of this enzyme9. PZA is well absorbed from gastrointestinal tract and is widely distributed to most tissues and fluid too18. The oral administration of 500 mg PZA produces plasma concentrations of 9-12ug/ml after two hours and 7ug/ml after 8 hours18. PZA is metabolized in liver whereas the metabolites are excreted through renal glomerular filtration18. Ethambutol (EMB) is discovered in 1962, acts as bacteriostatic agent and is active against undergoing cell division6, 19. EMB primarily targets on impairment of cell wall polymerization by inhibits arabinosy transferase, a vital enzyme responsible for mycobacteria cell wall biosynthesis9, 19. Since arabinosy transferase enzyme is encoded by embC-embA-embB genes, resistance against EMB evolved is believed due to mutation of these genes9. EMB is currently used as one of the first-line treatment for tuberculosis mainly because of its synergistic effect with other front-line drugs and its low toxicity property19. There is roughly 75-80% of an oral dose of EMB is rapidly absorbed in gastrointestinal tract with absorption unaffected when administered with foods20. In addition, EMB is distributed widely to body tissues and fluid, including cerebrospinal fluid before being metabolized in the liver and excreted in urine20. Streptomycin (SM) is an aminoglycoside antibiotic, used as first line treatment for TB when it first discovered in 19441, 6. Streptomycin is isolated from the bacteria Streptomycesgriseus and its antimicrobial effects against M. tuberculosisis highly effective when use in combination with other first line agents21. However, SM is no longer considered as first line treatment as resistance against it has developed rapidly1. The optimum pH for SM is at pH8 where its bacteriostatic activity will reduce with increasingly acidic environment21. SM acts by binding tightly to A site of 16S ribosomal RNA subunit, interferes with mRNA translation, causing faulty protein being produced1, 9. Resistant emergence when the mutation occurs at gene rpsL and rrs that encoded for 16S and S12 ribosomal protein1, 9. Upon administration, SM is poorly absorbed from gastrointestinal tract and mostly administered parentally1. SM is mostly excreted in urine and patients with low renal profile might experience toxicity such as neurotoxic reactions1. When the first line treatment is no longer suitable for patients or patients develop multi-drug resistance TB, second line drugs will then be introduced in combating the TB. Second line drugs that are mostly used include Ethionamide (ETH), Cycloserine (CS), Para-Aminosalicylic Acid (PAS) and Fluoroquinolones (FQ). ETH has been in use since 1960s, is a structural analogue of INH and it targets at inhibition of mycolic acid biosynthesis in tubercle bacilli9, 22. INH however is much more potent than ETH since the minimal inhibitory concentration for ETH is 0.5-5.0ug/mL22. Resistance evolved due to mutation at gene InhAand ethA which encode for oxygenase enzyme in activation of ETH 9. In vitro, CS has inhibitory effect on M. tuberculosis at 5-200ug/mL and there is no cross resistance occurred between CS and other drugs14. CS acts by interfereing the biosynthesis of bacterial cell wall14. CS is well absorbed in gastrointestinal tract and also widely distributed to body tissues and fluid including cerebrospinal fluid14. PAS was first introduced as first line drug but being replaced by Ethambutol in 1960s1. It acts bacteriostatically with possessing inhibitory effect at concentration less than 1mg/ml by interfere with folic acid metabolism in bacteria1. PAS is readily absorbed from gastrointestinal tract and distributed well throughout the body. Approximately 80% of the drugs will be excreted via kidney after being metabolized to acetylated form1. Moxifloxacin and Gatifloxacin are both been synthesized and evaluated as excellent bactericidal agents through inhibiting DNA gyrase, an ATP-dependent enzymes topoisomerase II which is responsible in bacteria DNA transcription9. DNA gyrase is consisted of two subunits that is arranged in a complex, is encoded by two different genes, gyrA and gyrB where mutations at gyrA will normally cause bacteria resistance to these new generation of flouroquinolones9. Due to the increasing incidence of multidrug resistance TB, it is highly desirable to develop new drugs that are not only potent and effective against current resistant strains of M. tuberculosis but also possess shorter treatment duration since most of the incompliance of patients is brought up by lengthy TB treatment. Most of the mechanisms of action of current treatments are involved in interfering the bacterial DNA synthesis, protein and mycolic cell wall biosynthesis. The enzymes that participate in these pathways could also be the target of newly designed drugs such as TMC207, one of the new drugs which are currently under investigations and clinical trials. TMC207 is a member of diarylquinoline class of compound which target at adenosine triphosphate (ATP) synthase by binding to subunit C of the synthase, blocking the energy pathway of mycobacteria23, 24. In vitro, TMC207 not only possesses ability to inhibit both drug sensitive and resistant M. tuberculosis isolates, but also able to sterilize the patient through killing the dormant bacilli bactericidally23. TMC207 showed a minimum inhibitory concentration of 0.03ug/mL against M. tuberculosis, suggesting a more potent agent compared to current first- line treatments such as isoniazid and rifampicin24. Apart from that, its synergistic effect with pyrazinamide could promise as effective drug combination for sterilizing the patients against TB23. A phase I clinical trials which involved short terms administration of TMC207 in healthy individuals showing no adverse effects and the subjects are well tolerated with it24. However, it is essential to investigate the selectivity of TMC207 again st mammalian ATP synthase with longer periods to ensure the patients safety when administered with TMC207. Thiacetazone (TAC) is widely used as second line anti-TB agent against multiresistant tuberculosis at present25. TAC acts by interferes the biosynthesis pathway of mycolic acid in tubercle bacilli25. The fact that M. tuberculosis has been difficult to eradicate and remains persistent is due to its cell wall that composed of mycolic acid which is resistant against chemical injury, dehydration and also has low permeability to antibiotics25. Mycolic acid contains cyclopropane rings that is activated through cyclopropane mycolic acid synthase (CMASs), has a significant contribution to tuberculosis25. By inhibiting the cyclopropanation, the cell wall biosynthesis will then be interrupted, introducing the bactericidal effects25. The aim of this research is to synthesis and evaluates the analogues of Thiacetazone which might be potential anti tuberculosis agents. The analogues will be tested against different strains of mycobacteriain lab. The target actions of these analogues will also be identified based on the structure of the analogues. The above analogue is synthesized when a benzylaldehyde reacts with a primary amine. This is a condensation process and an imine is produced. The changes at position R1 to R3 with different electron withdrawing groups are first planned to be evaluated. However, the plan is prohibited since the corresponding structures are either unavailable or too expensive that falling outside the budget. After revised on the previous analogues that were discovered and their respective MIC values obtained from lab, the structures of new analogues that are going to be evaluated are finally sorted out. The R1 to R3 positions would be replaced by either a -chloro or a -methoxy with R8 position would either be an amine, a methyl or a benzene ring. A chloro is used at position R1 to R3 since it is electron withdrawing, big and lipophilic molecule whereas the methoxy group is electron donating, small and quite lipophilic. For R8 position, an amine is selected because it is electron withdrawing and small. A methyl is also selected since it is quite lipophilic, small and electron donating. On the other hand, benzene ring which is highly lipophilic, neither electron donating nor withdrawing group might have a different effect on the analogue synthesized.

Old Man And The Sea :: essays research papers

In life, one will go through a number of stages in life. Infancy, Youth , Adulthood, and Old Age are all key stages. As one grows, they mature through these various stages. When one reaches old age, there is often a lot of doubt surrounding their lives. Serenity, and independence are often the two most questioned. These are some questions that Santiago has to ask himself as well.   Ã‚  Ã‚  Ã‚  Ã‚  In the novel The Old Man And The Sea, Ernest Hemingway develops the concept of man coming to the realization that as he ages, his dependency on others will increase. The use of metaphor is key in showing how this is indeed true. The struggle with the Tiburon represents the mental struggle that Santiago is having with himself. The Tiburon is also used as a metaphor for Santiago’s life. The boy in the story parallels what Santiago’s life once was.   Ã‚  Ã‚  Ã‚  Ã‚  The struggle with the Tiburon represents the struggle that Santiago is having with himself. The constant struggle makes Santiago realize that he is no longer as young as he thinks he is and he must rely on the help of others. This is shown when Santiago is battling the Tiburon. “ ‘Bad news for you fish’, he said and shifted the line over the sacks that covered his shoulders. He was comfortable, but suffering, although he did not admit to the suffering at all. ‘ I am not religious...but I will say Ten Hail Marys that I should catch this fish’... ‘Hail Mary full of Grace the Lord is with thee. Blessed art thou among women and blessed is the fruit of thy womb, Jesus. Holy Mary, Mother of God pray for us sinners now and at the hour of death, Amen.’ Then he added. ‘ Blessed Virgin, pray for the death of this fish, wonderful as he is.’ '; [ Hemingway 64-65]   Ã‚  Ã‚  Ã‚  Ã‚  This quote shows that the old man is forced to break the rules of sanity and talks to himself as well as the fish which cannot hear him. The old man thinks to himself that the fish is a “ “ God fearing '; fish and by saying the Hail Mary, the fish will give in and let himself be caught. After saying the Hail Mary the Old Man tries to convince himself that his previously hurt hand is okay, when really it is not.   Ã‚  Ã‚  Ã‚  Ã‚  In another part of the story Santiago admits that he is losing his sanity. “He did not want to look at the fish. He knew that half of him had been destroyed '; [Hemingway 114].

“Hamlet” Monologue Analysis Essay

The text to be or not to be by William Shakespeare refers to the paradox of life and death. He starts the poem by questioning himself: is it worth to exist or not, and by existing he is referring to the human ability of thinking; in the sense of: I exist because I can think. This issue is developed throughout the poem were the action of thinking deals with the decision of; should I live or not and it certainly becomes an obstacle to make that decision. In that sense the poem transmits that the innate human quality of thinking is what makes us weak instead of being a useful tool to make right decisions. In other words, despite we can perceive a solution to our problems (death), we are incapable of taking action (committing suicide) because we have the eternal problem of thinking. â€Å"To be or not to be, that is the question† this is the phrase that opens the poem, and in a sense, it is like a synthesis of what the author is going to explain later. He is referring to the verb â€Å"to be† practically the same as â€Å"to exist†. The question is: should I live? And by that he is considering that, by being humans, we have the ability to think. In some sort of way, Shakespeare is leading us to the paradox of life and death were human doubting is crucial in the understanding of the two, so there can be a decision. â€Å"to die, to sleep, No more; and by sleep to say we end the heart ache and the thousand natural shocks that flesh is hair to: it is a consummation devoutly to be wished† He is analyzing death and seeing it as the solution of the life he is living at the moment. In some way, he is confirming that being alive is a constant pain and so death is the unique pathway that would lead him to another life, a painless one. â€Å"Thus the conscience does make cowards of us all, and thus the native hue of resolution is slicked o’er with the pale cast of thought† This is the fragment in which the poem determines the reason why Hamlet haven’t decided yet nor taken action. This is the fragment were Shakespeare blames human thought for it being an obstacle when there is a decision to make, more precisely: human doubting explores the possible consequences of each action we are about to make, and by knowing them, we soon get afraid of our destiny  and of the unknown circumstances that will surrounds us later. Is an outlook to the future that force us to think back constantly. The doubt and the cowardness do not lead us anywhere. The text can be related to my life in the sense that it is the perfect explanation of the reason why we are afraid of making decisions. Every decision is premeditated and that is why we are uncapable of taking action. Besides, I believe that this reasoning of human thought as an obstacle when it comes to make a decision, applies to our daily life; We give up opportunities because we take a long time thinking, and that certainly is a huge obstacle to clarify our minds and make the right determination.

Essay on Causes of the Holocaust - 980 Words

Causes of the Holocaust The Holocaust took place for a number of reasons some of which were long term and others short term. The main reasons are; for centuries Germany had been an anti-Semitic country Jews were used as scapegoats for German problems. Also centuries of Nazi persecution caused the Holocaust in particular 1933 -1939 as well as Adolf Hitler and his racist views which influenced thousands of Germans. The Main reason for the holocaust happening was that Germany had been anti-Semitic for many centuries, and during those centuries the anti-Semitism had gradually got worse. Therefore because this was becoming a racial war, this was an opportunity for Germany to cleanse†¦show more content†¦In the 1930s the Wall Street crash occurred and the Jews having an image of being well educated and very wealthy and selfish due to all their large important businesses they ran in Germany. Hitler portrayed an image of the Jews to the Germans as though the reason why some Germans are out of jobs is because the Jews have stolen their jobs and are invading Germany being parasites and taking what belongs to pure hardworking German people. Therefore when the economic situation in Germany was very low and the German economy was suffering from the depression, the Jews were blamed for having all the German money and for Germans being very poor and starving during the time of the depression in the 1930s. Despite the fact the Jewish people were not particularly communist at all, due to Hitler being anti- communist, this was another act of using them as scapegoats. Anti - Semitism had been current in Europe for centuries, even since the days of Christ. Other religions blamed the Jews for Christs resurrection and were regarded as Christ killers. As years and centuries have gone by, the Jews were still being blamed for unfortunate events that there wasnt even evidence for. Thirdly I would like to add that there had been centuries of persecution from the Nazis in particular; 1933-1939. In 1933Show MoreRelatedThe Holocaust : The Causes Of The Holocaust804 Words   |  4 PagesAfter WW2, there was a thing called the holocaust. There were many concentration camps all over Germany where many Jews were killed in different ways. It happened between WW1 and WW2, 1933-1945. My position on why this happened is that Germany was going through a rough time, so Hitler wanted their country to resemble power. Read on to learn more about the causes and ways the Holocaust could have been avoided. The Holocaust was a mass slaying of groups of people which that Germany saw as inferiorRead MoreThe Causes Of The Holocaust1352 Words   |  6 PagesIn learning about the Holocaust I have found that the causes of the Holocaust are just as important as the injustice itself. There are many reasons the Holocaust was allowed to happen and many reasons it had become inevitable. One of the causes of the Holocaust was the need for a scapegoat. Like any thriving society Germany needed a lower class; a grouping of people that could be discriminated against. Hitler extended this to more than one group of people instead targeting everyone who wasn’t whatRead MoreCauses Of The Holocaust783 Words   |  4 PagesThe Holocaust was an atrocious and tragic event. Jews were forced into labor camps, mass murdered, turned into sex slaves, etc simply because they were seen as an inferior race towards the Nazis. 5-6 million Jews were killed during the Holocaust through starvation or murder. Their living conditions were unfathomable and the way they were treated was unthinkable. Jews lived in crammed spaces and were treated like animals which soon led them to act like animals. The perpetrators of genocide are usuallyRead MoreThe Holocaust : The Causes Of Hate In The Holocaust1424 Words   |  6 Pagespeople turn on one another with just feeling hate towards them? Th e Holocaust being one of the many genocides in our history was indeed influenced by an intense dislike. That intense dislike was towards certain types of people it ended up taking multiple lives. One of the many races that were hated, and killed during the Holocaust were the Jews. Jews had an average life before the Holocaust. According to the United States Holocaust Memorial Museum website, in 1933, there were about ten million JewsRead MoreThe Cause And Effect Of The Holocaust1811 Words   |  8 Pages2015 The Cause and Effect of the Holocaust Throughout the endless history, there were lots of important and influential event. For example the Dark Age, Enlightenment, Civil War, World War I and II and the Cold War. Over all of these event, there was one event that deeply influence the world and the Jews today, it was the Holocaust. Holocaust, a term that people use to describe the horrible event that happened during World War II which kill millions of innocent citizens. The Holocaust started atRead MoreEssay on Causes Effects of the Holocaust1422 Words   |  6 PagesCauses Effects of the Holocaust There are times in history when desperate people plagued by desperate situations blindly give evil men power. These men, once given power, have only their own evil agendas to carry out. The Holocaust was the result of one such mans agenda. In short simplicity, shear terror, brutality, inhumanity, injustice, irresponsibility, immorality, stupidity, hatred, and pure evil are but a few words to describe the Holocaust. A holocaust is defined as a disaster thatRead MoreEssay about Possible Causes of the Holocaust1903 Words   |  8 PagesMost of the world will no longer deny the mass murder of millions of Jews during World War II (1939-1945). The Holocaust is not a secret anymore. But was the Holocaust the brainchild of a deviant individual or was it an event that came only out of necessity? Was the Shoah intentional or was it functional? Or will we ever know for sure? The answer to that question is no, at least not presently. Historians searching for answers to the question of how the murder of a nation came about are oftenRead MoreThe Holocaust : Its Causes And How It Was Carried Out1497 Words   |  6 PagesDestiny Corbitt Shawn Underell The Holocaust 21 February 2016 The Holocaust The holocaust is one of the memorable events in history and it is important to know some of its causes and how it was carried out. The Holocaust is a controlled torture that killed roughly six million Jews by the Nazi government, led by Adolf Hitler. Apart from the Jews, other groups considered inferior or anti-establishment such as Poles, Romans and gypsies were also killed. There were several reasons for these grisly murdersRead MoreThe Holocaust was the genocide and the cause of death for about 6 million Jews during World War II.800 Words   |  4 PagesThe Holocaust was the genocide and the cause of death for about 6 million Jews during World War II. The Holocaust affected many, including Gypsies, homosexuals, mentally and physically disabled, and anyone who did not fit the description of Hitler’s â€Å"master race†. Hitler was an anti-Semitist who believed in a superior race and killed many Jewish people by putting them in concentration camps. Adolf Hitler was born in Austria on April 20, 1889 to Alois Hitler and Klara Polzl. He was the 4th out ofRead MoreThe Legacy Of The Holocaust859 Words   |  4 Pages As Nobel Laureate Elie Wiesel once said, â€Å"To forget a Holocaust is to kill twice,† that is why we are called to remember. Many movies, novels, and story representations of the Holocaust have been created in order to spread the memory of the past. An important part of remembering is learning, and therefore not repeating the same mistakes once again. Movies may find it difficult to represent the Holocaust accurately, while also giving it meaning and artistic expression. The writer, Edwin de Vries